Dre Greenlaw practiced for the first time this week since he tore his Achilles in the Super Bowl. Here's what head coach Kyle ...

The San Francisco 49ers promoted CB Nick McCloud to the active roster from the team's practice squad and activated LB Jalen ...

The first snow is beginning to fall at Highmark Stadium ahead of the Buffalo Bills' Week 13 bout with the San Francisco 49ers ...

The San Francisco 49ers have had issues with penalties this year, and now general manager John Lynch is speaking on the issue ...

The San Francisco 49ers (5-6) try to salvage their season against the Buffalo Bills (9-2) on Sunday Night Football. Kickoff ...

The San Francisco 49ers are making changes to their WR group ahead of an important road trip to face the Buffalo Bills.

The Buffalo Bills are set to return to action in Week 13 after enjoying their bye week, and they will be facing off against ...

San Francisco 49ers head coach Kyle Shanahan and quarterback Brock Purdy spoke with reporters after Friday's practice as the ...

The San Francisco 49ers expect to get quarterback Brock Purdy back for their Week 13 matchup with the Buffalo Bills. That’s ...

as the Bills host the San Francisco 49ers. This is the fifth time the Bills are playing in prime-time this year and they are ...

The 49ers travel to Buffalo to take on the AFC East-leading Buffalo Bills. Check out our best bet for the game ...

Watch out for the tables on "Sunday Night Football." The nightcap of Sunday's action will be in northern New York with the ...