There’s also been the conversation over the travel to Australia. The 49ers left last Thursday and arrived Friday, nearly a week before the game. The Rams left the US for their 17-hour flight on Tuesday with an arrival for Wednesday, one day ahead of the Thursday game. A lot of media members are pointing toward an advantage for the underdog 49ers.

The San Francisco 49ers need more of a running mate to go along with Nick Bosa. Moreover, the Niners shouldn’t put all their hopes of sacking the quarterback on Bosa, given his injury history; he’s dealt with tendinitis during training camp and the preseason.

There's a significant change to the San Francisco 49ers' depth chart following a brutal injury to one of their projected Week 1 starters.

The highlight addition that the San Francisco 49ers made this offseason was wide receiver Mike Evans. It was shocking to see he chose to sign with the 49ers. He

See our experts' final 49ers-Rams NFL Week 1 predictions for Thursday's matchup, with Christian McCaffrey listed among the best available player props.

El tackle defensivo de los 49ers de San Francisco Alfred Collins se perderá el resto de la temporada tras romperse el tendón rotuliano, informó el entrenador Kyle Shanahan el miércoles.

The 49ers need another proven edge rusher, and one analyst seems confident that they will go out and get one relatively soon.

The San Francisco 49ers' already thin defensive line sustained a devastating blow just days before their Week 1 kickoff vs. the Los Angeles Rams.