Should Guerendo start as expected Sunday, it will be just his second start as a running back since he was in the fourth grade ...

Ever since making the switch from high school receiver to running back in college, Isaac Guerendo has had few opportunities ...

The San Francisco 49ers have struggled to get Deebo Samuel going, and one NFL analyst thinks they may not be able to.

Get your game on! Whether you’re into NFL touchdowns, NBA buzzer-beaters, world-class soccer goals, or MLB home runs, our app ...

San Francisco 49ers linebacker Fred Warner recently revealed that he has been playing through a bone fracture in his ankle, ...

The San Francisco 49ers are a gigantic mess. Nothing looks right on offense. Injuries have decimated both sides of the ball.

The 49ers have lost three games in a row, but their season isn't dead yet. Sure, they're in last place in the NFC West, but ...

The San Francisco 49ers’ playoff chances aren’t completely erased, but they’re low enough that looking toward next year’s ...

There's even a chance Guerendo, who pulled his hamstring on the first day of training camp and missed the first two preseason ...

How should you approach Purdy with your Bills vs. 49ers NFL DFS picks? The 49ers have been decimated by injuries throughout ...

San Francisco has dropped three straight, including meek losses to the Packers and Bills by a combined 53 points, to drop to ...

NFL Week 14 odds, picks, predictions, TV channel, streaming information for Sunday football game between Chicago Bears and ...