ADME is the abbreviation for absorption, distribution, metabolism and excretion. ADME studies are designed to investigate how a chemical (e.g., a drug compound) is processed by a living organism.

Historically, it was not possible to detect ADME problems until the IND application preparation stage, which often led to “serious disruption of the development process, and often resulted in closure ...

In vitro ADME and drug-drug interaction (DDI) investigations are early activities in the drug development process that are critical for framing downstream decision making. Understanding the ADME ...