New York, NY - Doubts about the effectiveness of the new renin inhibitor antihypertensive aliskiren (Tektura, Novartis) have been voiced in a somewhat controversial review article in the May 2007 ...
San Diego, CA - Cardiorenal results from the multicenter Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE) trial, testing aliskiren (Tekturna, Novartis Pharmaceuticals) as an ...
Novartis announced today the early termination of the ALTITUDE trial, which was testing the effect of the direct renin inhibitor aliskiren (Rasilez, Tekturna) in type 2 diabetics at high risk for ...
Morning Overview on MSN
A common blood-pressure pill may be quietly speeding kidney damage in diabetics
Three large randomized trials tested a simple idea: if one blood-pressure drug that blocks the renin-angiotensin system ...
Diabetic nephropathy is the leading cause of end-stage renal disease in developed countries. We evaluated the renoprotective effects of dual blockade of the renin−angiotensin−aldosterone system by ...
Ischemic heart disease including myocardial infarction (MI) is the major cause of death in industrial countries. 1, 2 MI frequently causes left ventricular dilatation associated with cardiomyocyte ...
A subgroup analysis in heart failure patients with diabetes from the ATMOSPHERE trial has failed to show benefit and signals the end of the road for aliskiren in heart failure. The findings were ...
Are you taking Aliskiren? Are you aware of the dangers of combining Aliskiren with certain foods and herbs? Drug-food-interactions are seldom discussed but can lead to undesirable side effects and ...
Learn everything you need to know about Aliskiren and Hydrochlorothiazide-pronunciation, uses, dosage guidelines, indications, and when to take or avoid it. Get up-to-date information on side effects, ...
Last December the once-promising direct renin inhibitor aliskiren (Rasilez, Tekturna) suffered a fatal setback with the early termination of the ALTITUDE trial. The trial was stopped when the Data ...
The first evidence of the existence of renin was presented by Tigerstedt over 100 years ago. However, the importance of renin and the renin–angiotensin system (RAS) in the pathogenesis of ...
This study was undertaken to determine whether use of the direct renin inhibitor aliskiren would reduce cardiovascular and renal events in patients with type 2 diabetes and chronic kidney disease, ...
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