The anaphase promoting complex/cyclosome (APC/C) is a 1.5-MDa ubiquitin ligase complex that initiates sister-chromatid separation and exit from mitosis by targeting cyclin B and securin for ...

Proper chromosome segregation into two future daughter cells requires the mitotic spindle to elongate in anaphase. However, although some candidate proteins are implicated in this process, the ...

Errors in cell division can cause mutations that lead to cancer, and a new study could shed light on the role of chromosome abnormalities in uncontrolled cell replication. Researchers uncovered the ...