The biosynthesis of beta-lactam antibiotics centres on the assembly and modification of a four-membered lactam ring fused to a thiazolidine or dihydrothiazine moiety. In filamentous fungi and bacteria ...
Researchers have made a significant breakthrough in the field of asymmetric synthesis of beta-lactams, which are prominent in bioactive compounds. Their innovative approach employs nickel and ...
Beta-lactamase enzymes are a principal mechanism by which bacteria deactivate beta-lactam antibiotics, undermining treatments for a range of infections. Molecular dynamics approaches have become ...
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