c-Myc is broadly hyperactivated in colon cancer, yet the mechanisms sustaining its transcriptional activation remain elusive. Here we identify palmitic acid (PA) as a metabolite cue that activates ...
Scientists know that colorectal cancer cells require large amounts of iron and that as cancer becomes more aggressive, the ...
Colorectal cancer (CRC) progression critically depends on the tumor microenvironment. PLOD2, an enzyme involved in collagen biosynthesis, is highly expressed in many cancers. While it promotes CRC ...
Image Caption: Controversial effects of the STING pathway in colitis development. In colon cancer, the pathway shows a similarly complex profile. Activation of STING can stimulate immune defenses that ...
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