Final results from phase I study of PSCA-targeted chimeric antigen receptor (CAR) T cells in patients with metastatic castration resistant prostate cancer (mCRPC). This is an ASCO Meeting Abstract ...

Clonal hematopoiesis is the expansion of a genetically related population of hematopoietic stem and progenitor cells that disproportionately contribute to blood-cell production. 1 Clonal hematopoiesis ...

How do different cancer subtypes arise? Do they originate from distinct cells, or from a single multipotent cell capable of differentiating into multiple cell types? This question, debated for decades ...

In patients with cancer, clonal hematopoiesis was associated with cardiac toxicity and in increased risk of death due to heart conditions. While prior research has shown that clonal hematopoiesis can ...

Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition associated with increased mortality among patients with cancer. CHIP mutations with high variant-allele frequencies ...

A new editorial paper titled "Exploring clonal hematopoiesis and its impact on aging, cancer, and patient care" has been published in Aging. In this new editorial, researchers Julieta Elena Rodriguez, ...

Tumor-infiltrating clonal hematopoiesis increased the risk of disease recurrence or death among patients with cancer. TET2 mutations were the strongest genetic predictor of tumor-infiltrating clonal ...

Serial circulating tumor DNA analysis can demonstrate rapid clonal dynamics that evolve during response and resistance to both standard chemotherapy and targeted therapy of BRAF-mutant colon cancer ...

BOSTON – A new clinical tool developed by a team of researchers led by the Dana-Farber Cancer Institute pinpoints which Clonal hematopoiesis patients are at highest risk for cancer progression. Their ...

“Understanding the influence of prior treatments on CH [clonal hematopoiesis] dynamics is crucial for comprehending the intricate interplay between therapy, aging, and cancer.” While these detectable ...