Open Heart

Cardiac surgical outcomes and predictors of redo sternotomy in patients with Marfan syndrome: a retrospective multicentre cohort study

Background Marfan syndrome (MFS) is associated with progressive aortic and valvular disease requiring cardiac surgery, but ...
The BMJ

Outcome reporting in cohort studies of interventions

Guidance is needed to improve outcome definitions and reduce reporting bias Cohort studies of interventions complement ...
BMJ

Do the associations of daily steps with mortality and incident cardiovascular disease differ by sedentary time levels? A device-based cohort study

4 Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Providencia, Chile 5 Universidad de Santiago de Chile (USACH), Escuela de Ciencias de la Actividad Física, el Deporte y la Salud, ...
ascopubs.org

Using Dose-Escalation and -Expansion Cohort Study as Pivotal Trial for Targeted Anticancer Drug Approval

BRCA1-Associated Protein 1 and Enhancer of Zeste Homolog 2: Pathway Interaction and Therapeutic Intervention in Breast Cancer, Mesothelioma, and Lymphoma Early-phase clinical trials (EPCTs) have been ...
EurekAlert!

GLP-1 use linked to lower breast cancer incidence in large cohort study

The Penn Medicine study sets the stage for a multi-site clinical trial to determine whether GLP-1 drugs are associated with a lower risk of developing breast cancer. “While our study was observational ...
BMJ

Cardiorespiratory fitness is a strong and consistent predictor of morbidity and mortality among adults: an overview of meta-analyses representing over 20.9 million observations ...

Objective To examine and summarise evidence from meta-analyses of cohort studies that evaluated the predictive associations between baseline cardiorespiratory fitness (CRF) and health outcomes among ...

EXCLUSIVE: TransCode's RNA Therapeutic Achieves 64% Stable Disease Rate In Colorectal Cancer Phase 1 Study

TransCode Therapeutics, Inc. (NASDAQ:RNAZ) announced Wednesday that it has successfully completed the Phase 1a ...