When a wound does not heal properly, it leaves a scar. Similarly, mutations—which are permanent changes to genetic code—are ...

Cars patched up after a wreck may look fixed—but never run quite as before. The same may hold true for chromatin, according to a study published in Science on November 6. In response to double-strand ...

You may have seen it in the news recently: a baby in Pennsylvania with a rare genetic disorder was healed with a personalized treatment that repaired his specific genetic mutation. The treatment was ...

Inspired by long-lived animals — and human centenarians — researchers are hunting for ways to enhance DNA repair and extend ...

Cells are constantly subjected to DNA damage from a range of internal and environmental sources. It is estimated that cells can experience as many as 100,000 DNA lesions per day. One of the most ...

DNA damage poses a constant threat to genome integrity, especially in germ cells that transmit genetic information to ...

Targeted DNA editing by CRISPR technology has great potential for applications in biotechnology and gene therapy. However, precise gene editing remains a challenge largely due to insufficient control ...

A research team has identified the transcription factor C/EBPγ as a novel regulator that simultaneously promotes ...

HERSHEY, Pa. — When it comes to cancer, tumor suppressor genes are usually thought of as the “good guys.” These genes make proteins that protect and repair DNA in cells. If they stop functioning or ...

Cancer cells rely on powerful genetic switches to keep growth genes running at full speed, but that intense activity can damage their own DNA. The resulting breaks are repeatedly repaired, sometimes ...

An analysis of genetic data from over 900,000 people shows that certain stretches of DNA, made up of short sequences repeated over and over, become longer and more unstable as we age. The study found ...