NFL Week 2 score predictions, picks, betting odds for Buffalo Bills vs Detroit Lions game on Thursday, Sept. 17, 2026. Who will win Week 2 NFL game?

Dan Campbell and the Detroit Lions are getting some tough words thrown their way. Here's what's being said about the team.

On Tuesday, Sept. 15, the Detroit Lions added cornerback D.J. Reed to the practice report.

The Saints, down 21 points in the the third quarter, rallied to tie the game with 1:07 remaining and force overtime.

The Detroit Lions open their 2026 NFL season versus the Saints. Follow live score updates, highlights, injury news, key plays and instant analysis.

Explosive playmaker Jahmyr Gibbs and relentless edge rusher Aidan Hutchinson must dominate the trenches and open space to silence a hostile Buffalo crowd and secure a primetime victory.

The Detroit Lions won in overtime on Sunday, but many writers around the country are still worried about the team’s future. This week’s power rankings still put the Lions in the middle of the pack, just like last week. Heading into Week 2, they are ranked as high as No. 8 and as low as No. 14.

Outside linebacker Derrick Barnes intercepted a pass on the first play of the second half, setting up a Lions touchdown, then helped stop New Orleans' 2-point conversion attempt in overtime by getting into the flat quickly enough to take away Shough's passing lane to Chris Olave.