Calcium ions orchestrate contraction and relaxation in airway smooth muscle by regulating excitation–contraction coupling. In quiescent cells, basal cytosolic Ca2+ is maintained at nanomolar levels by ...

Fig. 1: Key players in skeletal muscle EC coupling: Ca V 1.1, Stac3 and RyR1. To solve this recent conundrum and definitively answer the age-old question of how excitation and contraction are coupled, ...

Instead, CICR acts as a dormant but dangerous silent risk factor, staying quiet under normal conditions yet becoming a major driver of pathology when RyR1 signaling is disrupted. This model resolves a ...