It has been 65 years since the scurfy mutation arose spontaneously in mice at the Oak Ridge National Laboratory in the United States, and it is 13 years since the molecular cloning of the forkhead box ...

The protein Foxp3 is vital to the function of immune cells called regulatory T cells, which control immune system activation. Despite its importance, how Foxp3 regulates the immune system using ...

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is caused by a missense mutation in the FOXP3 forkhead domain. Panel A shows normal frequencies of FOXP3-expressing ...

Thanks to regulatory T cells (Tregs), the immune system is kept in line via a careful system of checks and balances. Immune response too light? A viral infection spreads throughout the body. Immune ...

In this issue of Journal of Clinical Oncology, Merlo et al 8 suggest that FOXP3 is expressed in breast cancer cells, and the expression level is associated with patient survival. Using ...

Scientists at the Salk Institute say they have discovered that the Foxp3 protein is essential for creating the unique chromatin architecture of regulatory T cells and, in turn, promoting their immune ...

The immune system faces a delicate balancing act: it must be aggressive enough to fight infections and cancer, yet restrained enough to avoid attacking the body's own tissues. More than two decades ...

To investigate how FOXP3 dE2 affects tumor immune responses, Li and colleagues examined data from patients with triple-negative breast cancer in The Cancer Genome Atlas (TCGA) and analyzed survival ...

TBCRC009: A multicenter phase II study of cisplatin or carboplatin for metastatic triple-negative breast cancer and evaluation of p63/p73 as a biomarker of response. Background: Predictive markers of ...

Researchers determined the Foxp3 protein is actually a cofactor, hijacking DNA-binding proteins responding to the immunological environment of the T cell. Based on the type of response needed, ...