Single-cell profiling of nearly 2,000 people brings scientists closer to understanding the link between genetic variation, gene expression and health.

Aging alters DNA methylation, histone modifications, chromatin organization, and regulatory RNA activity, affecting gene ...

A Genome Medicine study finds differential expression outperforms allele-specific analysis for most genes, while CRISPR ...

BackgroundMuch of what we know about biology comes from animal models, particularly mice. Applying these insights to humans, however, is not always ...

Much of the phenotypic variation that is observed within and between species is the result of differences in gene regulation: specifically when, where and how much the genes are expressed. Given the ...

In three studies published in Nature today, Australian researchers have made advances in our understanding of how genetic ...

A research team has identified the core gene expression networks regulated by key proteins that fundamentally drive phenomena such as cancer development, metastasis, tissue differentiation from stem ...

A new study finds that the Alx4 gene shows divergent limb bud expression in chicken and mouse, yet its protein function ...

Sequencing the human genome was once thought to be the key to understanding genetic diversity and disease, but gene ...

Origin-recognition complex (ORC) plays an unexpectedly broad role in the regulation of human cell gene expression, according to a study in the journal Cell Reports. "This is the first detailed study ...

In biology classrooms, we often learn that genes are transcribed into mRNA, which is then translated into proteins—a tidy, linear process. But gene expression in living cells is far more intricate, ...

A research team at KAIST has identified the core gene expression networks regulated by key proteins that fundamentally drive phenomena such as cancer development, metastasis, tissue differentiation ...