For decades, scientists have known that motor proteins like kinesin-2 ferry vital cargo along microtubule "highways" inside cells. But how these molecular vehicles identify and bind to the right cargo ...

The kinesin-2 motor protein uses a hook-like adaptor and cargo-binding (HAC) domain to recognize and transport cargo along microtubule highways, revealing a cellular logistics system critical for ...

Regulation of organelle transport by molecular motors along the cytoskeletal microtubules is central to maintaining cellular functions. Here, we show that the ubiquitous tau-related ...

Motor proteins that pause at the ends of microtubules and produce pushing forces can also stimulate their growth, according to researchers at Penn State. The proteins' function could be a critical ...

Microtubules are protein fibers that facilitate the transport of cellular components throughout a cell’s interior. Within a cell, microtubules span from the nucleus to the cell membrane, and the motor ...

Molecular motors such as kinesin are essential cellular machines that convert the chemical energy of ATP hydrolysis into mechanical work. These proteins enable the directed transport of vesicles, ...