The authors propose dual functions for cysteinyl leukotrienes in mice for promoting mucosal mast cell expansion and stimulating acute sensitization to oral anaphylaxis through signaling to epithelial ...

5-Lipoxygenase (5-LO), a fatty acid oxygenase, is the central enzyme in leukotriene (LT) biosynthesis, potent arachidonic acid-derived lipid mediators released by innate immune cells, that control ...

Leukotrienes are bioactive lipid mediators derived from the 5-lipoxygenase pathway of arachidonic acid metabolism. In cancer, both leukotriene B4 (LTB4) and the cysteinyl leukotrienes (LTC4, LTD4, ...

New research in mice has shown that food-induced anaphylaxis is driven by distinct immune pathways involving inflammatory lipids called leukotrienes. The findings, published across two separate ...