The chicken major histocompatibility complex (MHC) represents a compact and evolutionarily distinct genomic region that plays a critical role in orchestrating adaptive immunity. Characterised by a ...

Sex differences in parasite load and immune responses are found across a wide range of animals, with females generally having lower parasite loads and stronger immune responses than males. Intrigued ...

Viruses employ a variety of strategies to escape or counteract immune responses, including depletion of cell surface major histocompatibility complex class I (MHC-I), that would ordinarily present ...

Antigen presentation by major histocompatibility complex (MHC) proteins is the caller ID of the immune system. On the cell surface, MHCs display peptides derived from cellular components or foreign ...

Major Histocompatibility Complex (MHC) molecules display antigens to T cells, immune cells that constantly check for infected or damaged cells. If T cells spot MHC molecules with foreign antigens or ...

Analyzing nearly 6,000 MHC-1 complexes, the research team discovered patterns that can identify these preferences and predict immune responses across a broad range of human populations. The HLA ...

The adaptive immune system is an antigen-specific structure that discriminates non-self molecules through the recognition of peptide antigens using receptor interactions between T-cells and ...

A new study suggests epigenetic changes at Type 1 diabetes susceptibility genes may explain the risk profile of children born ...

Within each individual’s immune system is a unique repertoire of billions of T cells patrolling the body to uncover and eliminate foreign threats. Yet this army is not foolproof and can miss the ...

In the ever-evolving world of cell therapy, researchers often turn to T cells—a type of white blood cell—to transform the way we treat cancer. This is true for CAR T therapy, a modern cancer ...