Studying the shape of tissues and organs is critical to understanding how they are formed. Embryonic development happens in three dimensions, but many studies are limited by the use of two-dimensional ...

Human embryos are extremely difficult to study. This lack of samples limits our understanding of crucial developmental stages, such as the early formation of blood cells. A stem-cell-based model ...

DNA is not randomly distributed within the nucleus but is packaged with proteins into chromatin, which is precisely folded ...

A new spatial 3D genomics technology called SpaceA maps long-range chromatin interactions inside intact mouse embryo tissue and uncovers a liver-specific genome folding mechanism that operates ...

Using CRISPR-based engineering methods to prompt stem cells to organize into embryo-like structures, scientists were able to create 'programmable' cellular models of embryos without ever experimenting ...

Bioengineering researchers at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have developed a soft, thin, stretchable bioelectronic device that can be implanted into a ...

Researchers have gained new insights into the mechanism behind the spatial organization of DNA within the cells of early embryos. When an embryo is first formed after fertilization, each cell has the ...

Their “programmable” embryo-like structures, also known as embryoids, can be used to study the role of certain genes in early development The earliest days after fertilization, once a sperm cell meets ...

For several years, researchers studied human embryonic stem cells (ESCs) to understand the unique features of these pluripotent cells, but on their own, they poorly resembled the complex structures ...