Kickoff in Las Vegas is set for 8:20 p.m. ET. Kansas City is a 7.5-point favorite in the latest Chiefs vs. Raiders odds from William Hill Sportsbook, while the over-under for total points scored is 56. Before you make any Raiders vs. Chiefs picks, be sure to see the latest Sunday Night Football predictions from SportsLine's proven model .

In Sporting News' first picks and predictions against the spread for the 2026 NFL regular season, the Seahawks and Rams get off to great starts as co-favorites in the NFC West, while the Giants and Eagles win in their opening NFC East matchups.

Garrett Nussmeier made a strong impression in his first NFL start as the Chiefs consider their quarterback options ahead of roster cuts.

Here's what you need to know about NFL Week 1 game odds between the Titans and Jets, which is being played at the Titans' Nissan Stadium at 10 a.m. MST (1 p.m. ET) and can be seen on CBS (stream on FUBO).

The Cowboys have a new-look defense with new defensive coordinator Christian Parker and first-round pick Caleb Downs. The John Harbaugh era begins in New York. Dak Prescott is 14-3 S/U against the Giants – and Dallas has won nine of the last 10 meetings.