Investigators at Dana-Farber Cancer Institute have developed a platform for systematically discovering molecular glues that ...

Setidegrasib, a first-in-class KRAS G12D degrader, uses the cell’s own recycling system to destroy a key cancer driver ...

A new active substance attacks a key protein in tumor cells, leading to complete degradation. In cell experiments, this caused cancer cells to lose their protection and die. The active substance was ...

A scalable platform to discover molecular glue degraders has been developed, identifying the first metabolically activated ...

Bristol Myers Squibb explores a new and distinct approach to multiple myeloma ...

Cells have a remarkable housekeeping system: Proteins that are no longer needed, defective, or potentially harmful are labeled with a molecular "tag" and dismantled in the cellular recycling machinery ...

Like any complex system, the cell depends on a tightly regulated quality control network to maintain order and prevent the accumulation of harmful proteins. This network governs protein homeostasis, ...

Certain cancer-driving proteins resist nearly all existing treatments, making many aggressive cancers effectively untreatable. Researchers devised a strategy to use protein-like polymers called ...

Protein kinases are the molecular switches of the cell. They control growth, division, communication, and survival by attaching phosphate groups to other proteins. When these switches are stuck in the ...

A new study outlines how cutting 3 specific protein building blocks from your diet by reducing protein could help you live ...