Membrane receptors regulate numerous intracellular functions. However, the molecular underpinnings remain poorly understood because most receptors initiate multiple signaling pathways through distinct ...

A deep dive into the Fc–FcR axis as a therapeutic anchor in autoimmune disease, examining immune signaling and drug ...

G protein–coupled receptors (GPCRs) play crucial roles in the regulation of a wide variety of physiological processes and represent one-third of targets with clinically prescribed drugs. Yet, it ...

Receptor tyrosine kinases (RTKs) regulate many critical biological processes such as cell growth, differentiation, and survival through the recruitment of intracellular signaling molecules. The ...

A collaborative study on a plant intracellular immune receptor not only shows how an important resistance protein is activated during pathogen infection but also reveals some common operational ...

From studies conducted on animals, evidence has emerged that both neutralizing activity and Fc-mediated effector functions of neutralizing antibodies provide some levels of protection against the ...

Christian Posch, Homayoun Moslehi, Luzviminda Feeney, Gary A. Green, Anoosheh Ebaee, Valentin Feichtenschlager, Kim Chong, Lily Peng, Michelle T. Dimon, Thomas ...

Research teams explore the activation of plant immune receptors by pathogens. In a recent study, Alexander von Humboldt Professor Jijie Chai at the University of Cologne and his team together with ...