The perception was that intratumoral T cells expressing LAG3 perform no function: they either just sit there or they die. So, it was both surprising and exciting to see that they can actually drive ...

T cell immunity plays a pivotal role in the host defence against SARS-CoV-2, complementing humoral responses and contributing to viral clearance, disease modulation and long-term protection. Upon ...

Researchers discovered a way to keep T cells from wearing out during the fight against cancer, and the approach could make immune-based treatments far more powerful. They found that tumors use a ...

As the immune system battles cancer, chronic stimulation gradually drives T cells to a state of exhaustion. But some of these ...

A new study by researchers at the Perelman School of Medicine at the University of Pennsylvania reveals that the ...

For decades, cancer immunotherapy has focused primarily on CD8 + cytotoxic T lymphocytes as the main executors of tumor cell killing. However, growing clinical and single-cell sequencing evidence ...

An experimental Zika vaccine protected mice through CD8+ T cells, offering a possible way to avoid worsening infection caused ...

Scientists have long believed that tissue-resident memory T cells—which remain in tissues after an infection has cleared and respond rapidly if the threat returns—are shaped primarily by biochemical ...

Finding out if you have celiac disease is not easy. Diagnosing the autoimmune disease in the United States requires two tests. First, a blood test to identify elevated levels of certain antibodies, ...

The immune system may learn not to attack the body by using a small but representative sample of the body’s own protein ...