The San Francisco 49ers, led by quarterback Mac Jones, face the Houston Texans, led by quarterback C.J. Stroud, on Sunday, Oct. 26, 2025 at NRG Stadium in Houston, Texas.

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Kickoff from NRG Stadium is set for 1 p.m. ET, and the Texans are 2.5-point favorites, according to the latest 49ers vs. Texans odds. The over/under for total points scored is 42. The Texans are -151 money line favorites (risk $151 to win $100),