Bickley & Marotta discuss the upcoming test for the Arizona Cardinals as they face the Super Bowl champion Seattle Seahawks in Week 2 of the NFL season. Both teams come into the game after winning in Week 1.

Mike Florio unpacks how the Seahawks' 11-game win streak (including playoffs), nine-game win streak against the Cardinals and Arizona's losing streak at home all paint a dismal picture for the home team.

Lorenzo Alexander joins Wolf & Luke to discuss the Arizona Cardinals' upcoming game. The guys break down if the team will have a better chance at upsetting the Seattle Seahawks now that it is confirmed Drew Lock will be the starting quarterback due to Sam Darnold's injury.

Seattle Seahawks vs Arizona Cardinals picks, predictions, odds, win probabilities for NFL Week 2 Sunday game on Sept. 20, 2026. Who will win game?

The Arizona Cardinals host the Seattle Seahawks at State Farm Stadium on Sept. 20 and USA TODAY's NFL experts have locked in their picks for the action.