The LA Rams will face the San Francisco 49ers in the first regular season American football game to be played Down Under.

Melbourne businesses are forecast to see a major economic lift this weekend, as the city hosts Australia's first regular season NFL match — a sold-out clash between the Los Angeles Rams and San Francisco 49ers.

Get all the key details, including broadcast times and commentators, ahead of the 49ers v Rams clash at the MCG.

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Friday’s game between the 49ers and Rams at the MCG is almost sold out with millions more set to watch on Netflix

NFL fever has gripped Australia with thousands of fans gathering in Melbourne ahead of the historic clash between San Francisco 49ers and the LA Rams.

With only two Victorian teams left in the AFL finals series, Melbourne is going all in on American football instead.

NFL giant Seattle Seahawks has planted a flag in Australia, signalling their intention in the region by linking up with AFL powerhouse Collingwood.