The Houston Texans are talented enough to make the next step, but these three things could prevent them.

Among the Week 1 matchups across the NFL landscape, an AFC matchup has the billing of a game you more than likely may see in the playoffs in a matter of months. The Houston Texans host the Buffalo Bills in Week 1 at Noon on CBS.

The Houston Texans host the Buffalo Bills at Reliant Stadium on Sept. 13 and USA TODAY's NFL experts have locked in their picks for the action.

The Houston Texans' second-round rookie appears to be progressing well.

The NFL season is finally here, and one of the most anticipated games of opening weekend will take place when the Houston Texans host the Buffalo Bills on Sunday. Even before kickoff, Texans star pass rusher Will Anderson Jr.

The Texans have a championship-level defense. There are stars at every level of it. They want to hit the opponent often and make it hurt. But defense doesn't sell as easily as a good offense, especially one with an elite quarterback. That is a reason the Bills are favored by a point in a great Week 1 matchup.

Houston Texans star Will Anderson Jr. expects a playoff atmosphere for their Week 1 game against the Buffalo Bills.

The Houston Texans got a steal with their trade for wide receiver Kayshon Boutte.That much was true before his veritable replacement, AJ Brown, suffered an injury during the New England Patriots’ season-opening loss to the Seattle Seahawks.

The Cowboys have a new-look defense with new defensive coordinator Christian Parker and first-round pick Caleb Downs. The John Harbaugh era begins in New York. Dak Prescott is 14-3 S/U against the Giants – and Dallas has won nine of the last 10 meetings.

Buffalo Bills vs. Houston Texans - Betting Preview for September 13, 2026