A comprehensive preview, including betting odds and predictions, for the NFL game between the San Francisco 49ers and Los Angeles Rams on Sept. 10, 2026.

In the first "Thursday Night Football" game of the season, we technically have a Friday afternoon game, as the Los Angeles Rams "host" the division rival San Francisco 49ers in the first NFL game game that will be played in Melbourne,

It’s fitting, too, that the Los Angeles Rams and the San Francisco 49ers will be playing their season-opening game Thursday (7:35 p.m. CT, Netflix) at the Melbourne Cricket Ground — known locally as the MCG or, more commonly, just as The G.

The Los Angeles Rams and San Francisco 49ers will battle at Melbourne Cricket Ground in Australia, marking the first-ever football game on the continent. Netflix successfully added the game to its schedule this year, which features five different games through the end of the regular season.

Christian McCaffrey is on the verge of breaking a longstanding NFL record in the 49ers' Week 1 game against the Rams.

La Canfora then argues that these issues are emblematic of “a team ... that is in steep decline.” He makes the not-quite-novel observation that a team of older players are making their “last stand,” and he even suggests Kyle Shanahan could leave SF for Washington after his contract ends in 2027.

The 49ers asked the NFL for a Monday night Week 2 game after opening the season in Australia. Kyle Shanahan revealed the league denied the request.