Nature

Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR

Both the dendritic cell receptor DC-SIGN and the closely related endothelial cell receptor DC-SIGNR bind human immunodeficiency virus and enhance infection. However, biochemical and structural ...
Nature

Most DC-SIGNR transcripts at mucosal HIV transmission sites are alternatively spliced isoforms

Vaginal tissues were collected from 13 HIV-1 uninfected women undergoing vaginal repair surgery at the University of Washington and Swedish Medical Center in Seattle. Rectal biopsies (3–4 mm) were ...