Huntington’s disease (HD) is caused by an expansion of a short DNA sequence — the letters C-A-G — located in the very first ...
In people with premanifest HD, lower scores on the visual thinking tests were linked with more movement changes over time.
A new Phase 1 study is testing SRP-1005, a huntingtin-lowering therapy given by injection under the skin. It’s early days, but this approach could add an important new arrow to the HD drug development ...
Spark and Roche issued a joint community letter to share that the first patient has been dosed in a new HD gene therapy trial. To capture your interest with a romance, let’s talk about how these ...
In plain language. Written by scientists. Two individuals with the same CAG repeat count can have vastly different HD journeys. A new study looking at individuals with 36-42 repeats shows that DNA ...
In plain language. Written by scientists. August was another busy month for HD research! Learnings from past trials, new approaches to huntingtin lowering, the start of INSIGHTT and PRECISE-HD, three ...
HSG leadership is kicking things off with a series of intros and brief updates about the meeting agenda and the future of the organization. Stay tuned today as well as Friday and Saturday as we share ...
The expanded CAG repeat that causes HD sits within the very beginning of the huntingtin gene. Sometimes the huntingtin message gets cut short, producing smaller fragments. One shortened product that ...
⏱️ 9 min read |New research in a HD mouse model points to a key culprit: a small fragment called HTT1a. Lowering HTT1a levels successfully delayed disease signs in mice that model HD, perhaps shaping ...
Many people living with Huntington’s disease (HD) lose motivation to carry out some tasks. A new study shows that these apathetic behaviors are because of a change in the brain’s ability to weigh cost ...
Huntington’s disease (HD) is typically viewed as a brain disorder, but new research highlights its lesser-known effects on the body, especially on muscles, fat, and nutrition, even in the early stages ...
August has been a packed month for Huntington’s disease (HD) research. We’ve looked at what can be learned from disappointing ...
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