The San Francisco 49ers are just starting to figure out how they want to deploy their personnel on defense with Robert Saleh. We saw a wrinkle in Week 2 that we did not see in Week 1 involving Ji’Ayir Brown coming in as a third safety rather than the team playing Luke Gifford or Upton Stout.

Injuries are already biting the San Francisco 49ers after two of their top players were dinged up last week in the season-opening win over the Seattle Seahawks, yet the Niners are still 3-point favorites and popular NFL survivor picks in Week 2 as they visit the New Orleans Saints.

The San Francisco 49ers started Mac Jones at quarterback, and defensive end Nick Bosa was impressed by his swagger on Sunday.

Mac Jones National Football League San Francisco 49ers Top Plays NFL - San Francisco 49ers vs. New Orleans Saints - 09/14/2025

Quarterback Mac Jones likely didn't envision when he joined the San Francisco 49ers in March that he would make his first start for the club before the official end of summer arrived.  "I knew what I wanted,

The San Francisco 49ers downed the Seattle Seahawks in Week 1. How did it affect how Kyle Shanahan's team is being viewed in Week 2.

Kyle Shanahan's team could be without quarterback Brock Purdy for nearly a month after the 49ers won their opening NFL game.

The Week 2 NFL schedule continues with star-studded matchups throughout the weekend. Sunday's slate includes Bills (-6.5) at Jets, Steelers (-3) vs. Seahawks and Colts (+2.5) vs. Broncos. Bettors who are looking for how to bet on the NFL will also want to check out the Chiefs (+1.