The San Francisco 49ers suffered a pair of huge blows to their offensive backfield in their Week 13 loss to the Buffalo Bills ...

The 49ers lost running back Christian McCaffrey for the season with a knee injury. His backup, Jordan Mason, will also be ...

The San Francisco 49ers have had horrible luck with injuries, especially at running back. They lost Elijah Mitchell before the season began, then Christian McCaffrey missed the first two months, and ...

The San Francisco 49ers’ dreadful season got worse in Week 13 when running backs Christian McCaffrey and Jordan Mason both ...

The San Francisco 49ers could say goodbye to RB Jordan Mason, one of their most productive offensive players, in the near ...

San Francisco 49ers running back Jordan Mason is going on injured reserve, head coach Kyle Shanahan announced.

The San Francisco 49ers placed running back Christian McCaffrey on injured reserve Tuesday a day after coach Kyle Shanahan ...

Running back Christian McCaffrey will go on injured reserve with a posterior cruciate ligament strain that may not need ...

The San Francisco 49ers entered this season with lofty aspirations. For the most part, their hopes have been dashed -- and ...

The 49ers are down to one healthy RB, rookie Isaac Guerendo. They will likely elevate Patrick Taylor Jr. from the practice ...

As injuries once again define a 49ers NFC title defense, the team still has some silver linings in the form of defenders ...

San Francisco 49ers rookie running back Isaac Guerendo is dealing with a foot injury and is listed as questionable for Week 15 against the Los Angeles Rams on T ...