San Francisco 49ers rookie running back Isaac Guerendo is dealing with a foot injury and is listed as questionable for Week 15 against the Los Angeles Rams on T ...

With San Francisco 49ers running back Christian McCaffrey dealing with Achilles tendinitis to begin the year, Jordan Mason ...

Alisyn Camerota Announces CNN Exit After 10 Years A huge Buddha statue appeared by a road in New Jersey. Then the worshippers ...

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

Rookie running back Isaac Guerendo left late in the fourth quarter of the 49ers' 38-13 win over the Chicago Bears with what most likley is a high ankle ...

San Francisco 49ers head coach Kyle Shanahan provided injury updates following Sunday's 38-13 victory over the Chicago Bears.

Watch San Francisco 49ers tight end George Kittle's Week 14 highlights as he caught six passes for 151 yards against the ...

San Francisco 49ers TE George Kittle slips through a crease for a 33-yard burst up the sideline. Watch highlights from San Francisco 49ers wide receiver Jauan Jennings in Week 14 as he caught seven ...

The 49ers have lost both of their top running backs to injuries. So how who will replace Christian McCaffrey and Jordan Mason ...

It's the final week of byes and also the swan song for the regular season in some fantasy leagues, making for an intriguing ...

Now with Christian McCaffrey and Jordan Mason out with injuries for San Francisco, that could all change with Guerendo set to ...

San Francisco 49ers star defensive end Nick Bosa will miss his third straight game after being downgraded to out for Sunday's ...