The LA Rams will face the San Francisco 49ers in the first regular season American football game to be played Down Under.

Get all the key details, including broadcast times and commentators, ahead of the 49ers v Rams clash at the MCG.

Melbourne businesses are forecast to see a major economic lift this weekend, as the city hosts Australia's first regular season NFL match — a sold-out clash between the Los Angeles Rams and San Francisco 49ers.

NFL Network Insider Ian Rapoport shares the recent development that San Francisco 49ers tight end George Kittle is cleared to play tonight in Week 1 against the Los Angeles Rams in Melbourne, Australia.

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Friday’s game between the 49ers and Rams at the MCG is almost sold out with millions more set to watch on Netflix

NFL fever has gripped Australia with thousands of fans gathering in Melbourne ahead of the historic clash between San Francisco 49ers and the LA Rams.

With only two Victorian teams left in the AFL finals series, Melbourne is going all in on American football instead.