QB Brock Purdy injured his shoulder in Week 11 against the Seattle Seahawks and wound up missing the team’s blowout Week 12 ...

Christian McCaffrey was viewed as the savior for the San Francisco 49ers. His return was supposed to cure all of the ...

The results were ugly for the San Francisco 49ers last week against the Green Bay Packers without starting quarterback Brock ...

The USC Trojans retired current Chicago Bears quarterback Caleb Williams' number on Saturday during halftime of their game ...

The announcement of Sheriff Chad Chronister came after President-elect Donald J. Trump said that he would impose tariffs that ...

Dre Greenlaw practiced for the first time this week since he tore his Achilles in the Super Bowl. Here's what head coach Kyle ...

"Sunday Night Football" in Week 13 sees the San Francisco 49ers taking on the Buffalo Bills. Here's the latest on a snowy ...

The Buffalo Bills will host the San Francisco 49ers at Highmark Stadium in Orchard Park, New York, on Sunday, December 1, at ...

Highest snow accumulations expected east of Lake Ontario, where some isolated areas could get hit by up to 60 inches of snow.

Analyzing Sunday’s San Francisco 49ers at Buffalo Bills odds and lines, with expert NFL picks and predictions.

Related: Bills Can Make History vs. 49ers on 'SNF' "Lots of things can happen between now and then, but right now he's ...

The Buffalo Bills announced Saturday that they are activating Matt Milano off injured reserve. It puts the linebacker in a ...