QB Brock Purdy injured his shoulder in Week 11 against the Seattle Seahawks and wound up missing the team’s blowout Week 12 ...

Christian McCaffrey was viewed as the savior for the San Francisco 49ers. His return was supposed to cure all of the ...

The results were ugly for the San Francisco 49ers last week against the Green Bay Packers without starting quarterback Brock ...

The USC Trojans retired current Chicago Bears quarterback Caleb Williams' number on Saturday during halftime of their game ...

The announcement of Sheriff Chad Chronister came after President-elect Donald J. Trump said that he would impose tariffs that ...

Dre Greenlaw practiced for the first time this week since he tore his Achilles in the Super Bowl. Here's what head coach Kyle ...

New York Gov. Kathy Hochul is declaring a state of emergency for the state's first big snowstorm of the season.She warns it ...

"Sunday Night Football" in Week 13 sees the San Francisco 49ers taking on the Buffalo Bills. Here's the latest on a snowy ...

The Buffalo Bills will host the San Francisco 49ers at Highmark Stadium in Orchard Park, New York, on Sunday, December 1, at ...

Running back Christian McCaffrey says the 49ers are “hungry” to make a playoff push even with the defending NFC champions ...

Highest snow accumulations expected east of Lake Ontario, where some isolated areas could get hit by up to 60 inches of snow.

Analyzing Sunday’s San Francisco 49ers at Buffalo Bills odds and lines, with expert NFL picks and predictions.