Over time, the neighborhood falls into disrepair. A critical protein that MSNs need to stay alive, called DARPP-32, starts to ...

Participants in a PET study received the tracer, then gave it time to reach the brain. Then they laid in a scanner that took ...

On June 2, 2025, uniQure shared that they’re aligned with the FDA about moving forward with their HTT-lowering gene therapy, AMT‑130. If the next round of results from their ongoing trial continues to ...

Spark and Roche issued a joint community letter to share that the first patient has been dosed in a new HD gene therapy trial.

Minocycline: the end of the road? DOMINO clinical trial result: minocycline doesn’t slow down HD and shouldn’t be studied in larger trials.

TRACK-HD reveals significant changes in pre-symptomatic HD mutation carriers and patients The one-year report from the TRACK-HD study demonstrates a number of changes in pre-symptomatic HD-mutation ...

The latest instalment in a series of big studies to understand the genetics of Huntington disease (HD) just hit the shelves. These studies have focused on how small changes in the genetic letters of a ...

Huntington’s disease (HD) is caused by a single genetic mutation, yet people with HD can experience vastly different symptoms – from movement issues to emotional struggles. A new study dives into ...

We all have days when we feel irritable, like when you’re stuck in traffic, or someone cuts in line at the grocery store. But for people living with Huntington’s disease (HD), irritability isn’t just ...

Welcome to Brainland, the bustling, 24/7 theme park in your head. There’s Memory Maze, Logic Log Flume, and of course, the Emotion Coaster, where your brain races through tracks themed around ...

Dimebon: disappointing in Alzheimer’s but might work in HD Dimebon – disappointing results in an Alzheimer’s disease trial, but hope remains for HD.