EMBO Press2d
Getting to the heart of cardiovascular complications associated with inflammatory arthritis
Inflammatory arthritis encompasses a group of autoimmune diseases, including rheumatoid arthritis (RA), psoriatic arthritis ...
EMBO Press6d
HAND1 level controls the specification of multipotent cardiac and extraembryonic progenitors from human pluripotent stem cells
How cardiac cell fates are specified during heart development remains elusive. This study identifies a level-dependent role ...
EMBO Press3d
Metabolic reaction fluxes as amplifiers and buffers of risk alleles for coronary artery disease
Using genetically predicted metabolic reaction fluxes, the authors identify reactions that can amplify or buffer the effect ...
EMBO Press5d
Dimerization of GAS2 mediates crosslinking of microtubules and F-actin
GAS2 is a cytoskeletal regulator that interacts with both F-actin and microtubules. Here, cryo-EM structures of GAS2 domains ...
EMBO Press12d
PARP7 as a new target for activating anti-tumor immunity in cancer
PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...
EMBO Press10d
Beyond mitotic arrest: the diverse effects of microtubule-targeting drugs on tumor vasculature
For decades microtubule-targeting agents (MTAs) have been a cornerstone of cancer treatment regimens and continue to be heavily employed as backbone chemotherapy in combination with new targeted ...
The EMBO Journal12d
Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Immune memory plays a critical role in the ...
The EMBO Journal9d
HDAC6 deacetylates ENKD1 to regulate mitotic spindle behavior and corneal epithelial homeostasis
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Corneal diseases can cause severe visual ...
The EMBO Journal5d
Multi-epitope immunocapture of huntingtin reveals striatum-selective molecular signatures
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Huntington’s disease (HD) is a debilitating ...
The EMBO Journal6d
SIRT5-mediated desuccinylation of PPA2 enhances HIF-1alpha-dependent adaptation to hypoxic stress and colorectal cancer metastasis
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Metastasis is the primary cause of death in ...
The EMBO Journal5d
T-cell-derived IFN-γ suppresses T follicular helper cell differentiation and antibody responses
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Subcutaneous LCMV infection induces T H 1 cell ...
The EMBO Journal5d
T-cell-derived IFN-γ suppresses T follicular helper cell differentiation and antibody responses
This cover highlights the article PLK1 inhibition delays mitotic entry revealing changes to the phosphoproteome of mammalian cells early in division by M. Gobran, P. Lenart and colleagues. HeLa Kyoto ...