The 7-week-old male C57BL/6J mice were acquired from the Nanjing Model Animal Research Center and kept in the SPF animal laboratory (temperature of 22 °C ± 2 °C under a 12-h light/dark cycle) with ...

Gastric cancer (GC) is characterized by highly heterogeneous tumors, whose progression is genetically driven and closely associated with hypoxia and an immunosuppressive tumor microenvironment (TME).

ABSTRACT: Endometriosis (EMs), a prevalent chronic inflammatory disease among women of reproductive age, has a global prevalence of 10% - 15% and is closely associated with 30% - 50% of infertility ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Non-Commercial (NC): Only non-commercial uses of the work are permitted.

The Editors of Stroke are issuing an Expression of Concern regarding article, “CCR5 Activation Promotes NLRP1-Dependent Neuronal Pyroptosis via CCR5/PKA/CREB Pathway After Intracerebral Hemorrhage” ...

To explore the effects of arabinoxylan on the BDNF/TrkB/p-CREB signaling pathway in the prefrontal cortex of post-stroke depressed rats, and to explore its neuronal protective effects through the ...

Select members of the Wnt family of secreted glycoproteins have been implicated in inducing the myogenic determinant genes Pax3, MyoD and Myf5 during mammalian embryogenesis(1,2), but the mechanism of ...

While sparking excitement among biopharma companies focused on rare and ultrarare indications, experts say FDA Commissioner Marty Makary’s proposal is light on details and raises potential concerns ...

Mitogen-activated protein kinase (MAPK) and Wnt signaling pathways are critical for melanocyte development and melanogenesis and could be novel therapeutic targets for modulating melanin synthesis.