During gastrulation, sequentially lineage-restrictive mesodermal cell populations emerge along a developmental trajectory involving primitive streak to lateral mesoderm formation, followed by cardiac ...

To inform on the complexity of heart diseases, multi-tissue morphogenic heart models are needed that ... the WNT/β-catenin pathway with the GSK3 inhibitor CHIR99021 to induce mesoderm differentiation ...

Researchers have developed a way of bioprinting tissues that change shape as a result of cell-generated forces, in the same way that it happens in biological tissues during organ development.

These three types of tendons tissues are derived from different origins, with the relevant information described above. The tendons in limbs are originated in the lateral plate mesoderm (LPM). LPM ...

Moreover, induction of endoderm and head-mesoderm, which require peak Nodal-signaling levels, is highly variable in explants, reminiscent of embryos with reduced Nodal signals from the extraembryonic ...

Cardiac muscle tissue, or myocardium, is a type of muscle tissue that forms the heart. It contracts and releases involuntarily and keeps the heart pumping blood around the body. The human body ...

By adding several substances to iPS cells, the Osafune team succeeded in generating intermediate mesoderm tissue, of which kidneys are largely composed, after 11 days of cultivation. They reported a ...