When the Rams take on the 49ers on Thursday night, the veteran quarterback will try to set a personal milestone with another ...

San Francisco 49ers running back Christian McCaffrey was the near-consensus No. 1 pick in fantasy football drafts. However, ...

Head coach Kyle Shanahan and defensive coordinator Nick Sorensen shared injury updates on RB Isaac Gurendo, DL Nick Bosa and more and discussed how the team is preparing for a short turnaround ahead ...

San Francisco 49ers running back Christian McCaffrey (knee) suffered a PCL injury just four games into his return from the ...

San Francisco 49ers head coach Kyle Shanahan provided injury updates following Sunday's 38-13 victory over the Chicago Bears. Rookie running back Isaac Guerendo, starting in place of the injured ...

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

Already missing five starters during the blowout loss to the Bills, San Francisco lost star running back Christian McCaffrey ...

SportsLine's model simulated Chicago Bears vs. San Francisco 49ers 10,000 times and made its Week 14 NFL picks, predictions ...

The San Francisco 49ers are facing another setback as defensive lineman Nick Bosa is officially out for Sunday's game.

Since returning from an Achilles tendinitis issue, Christian McCaffrey has dominated the San Francisco 49ers' backfield, playing 88% of the offensive snaps. In contrast, Jordan Mason has seen just 8% ...

With Christian McCaffrey on the shelf, the 49ers will turn to RB Isaac Guerendo, and he will deliver in Week 14 against the Bears!

Both of these teams are nowhere near where they'd like to be this season, but with one finding a rejuvenated energy to ...