The 28-year-old took to social media on Wednesday to share a heartfelt message for 49ers fans after his injury-plagued ...

San Francisco 49ers running back Christian McCaffrey was placed on injured reserve for the second time this season after ...

Having suffered a knee injury that landed him on injured reserve during a snowy loss to the Bills on Sunday night, 49ers ...

Running back Christian McCaffrey is on injured reserve for the second time this season, but San Francisco 49ers coach Kyle ...

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...

Christian McCaffrey practiced little and played less this season, seeing action in four games with 65 touches. He is out for the season with his knee injury that will require a six-week recovery.

McCaffrey was initially said to be out at least six weeks — with five weeks left in the season. Niners head coach Kyle ...

Since returning from an Achilles tendinitis issue, Christian McCaffrey has dominated the San Francisco 49ers' backfield, playing 88% of the offensive snaps. In contrast, Jordan Mason has seen just 8% ...

The plan appears to be a heavy dose of Guerendo with the only other halfbacks on the roster being Patrick Taylor, who has 72 ...

McCaffrey immediately checked himself out of the game and ran right into the medical tent. The 49ers star RB missed the ...

The 49ers superstar made the statement in a lengthy caption on his Instagram fee after the team put him on injured reserve ...

Christian McCaffrey suffered a PCL injury in the 49ers' Week 13 loss to the Bills. He addressed the injury on social media ...