The first real test for each team. The matchup was announced 10 years ago and will be Mississippi State's first visit to the state of Minnesota and first regular-season game against a Big Ten team since 1980. Illinois won at Duke 45-19 last season and easily handled UAB in its 2026 opener.

The Sooners weren't at their best against UTEP, and the Wolverines will test their improvement.

Oklahoma Sooners vs Michigan Wolverines Game Preview

Our early Oklahoma vs. Michigan predictions expect the Sooners to get a win in a game that be controlled by the defenses.

Greg McElroy predicts the Oklahoma Michigan Week 2 showdown, picking a winner and final score. Here is his reasoning plus what both teams bring to Ann Arbor.

College football Week 2 odds, picks, predictions, projections, TV channel, streaming for Michigan Wolverines vs Oklahoma Sooners game Sept. 12, 2026.

Bryce Underwood and the Michigan Wolverines take on the Oklahoma Sooners in Week 2. Get expert Michigan-Oklahoma predictions, player prop distributions, and live Polymarket trends.

Oklahoma coach Brent Venables isn't buying the negative talk about Michigan, despite the Wolverines needing a Hail Mary to beat Western Michigan last Saturday.

No. 11 Oklahoma (1-0) at Michigan (1-0), Sept. 12 at 12 p.m. EDT. Opening Line: Oklahoma by 5.5. Against the spread: Oklahoma 1-0, Michigan 0-1. How to watch: FOX Key stats Oklahoma Offense Overall: 401 yards per game (70th in FBS) Passing: 231 yards per game (69th) Rushing: 170 yards per game (63rd) Scoring: 51 points per game (26th) Oklahoma Defense Overall: 198 yards per game (30th in FBS) Passing: 86 yards per game (12th) Rushing: 112

Michigan's defense has a tall task on Saturday afternoon — containing dual-threat Oklahoma quarterback John Mateer. In a 24-13 win over Michigan last season, Mateer threw for 271 yards, rushed for 74 with one passing touchdown and two rushing scores.