May 5, 2022 · Holoprosencephaly (HPE) is a birth defect (congenital condition) that causes the fetal brain to not properly separate into the right and left hemispheres (halves). HPE ranges in severity …

Holoprosencephaly (HPE) is a condition that changes the way a baby’s brain develops. In HPE, the left and right sides of the brain do not separate like they should.

Holoprosencephaly (HPE) is a cephalic disorder in which the prosencephalon (the forebrain of the embryo) fails to develop into two hemispheres, typically occurring between the 18th and 28th day of …

Jun 7, 2024 · Holoprosencephaly is a rare and complex congenital disorder that significantly impacts the development of the human brain and occurs due to anomalous signaling interactions between the …

Feb 4, 2025 · Holoprosencephaly (HPE) is a congenital defect of the forebrain (i.e., prosencephalon) and midline structures, resulting in incomplete separation of the cerebral hemispheres in the midline, …

Mar 13, 2024 · Holoprosencephaly (HPE) is a rare congenital anomaly in which an embryo’s brain does not properly divide into two halves, known as the left and right hemispheres. HPE affects brain …

Jan 1, 2026 · Holoprosencephaly (HPE) is a rare congenital brain malformation resulting from incomplete separation of the two hemispheres. Classically three subtypes have been recognized, …

Oct 4, 2024 · Holoprosencephaly (HPE) is a rare and complex brain malformation that occurs during fetal development. This condition affects the brain's structure and function, leading to a wide range of …

This leaflet is to help you understand what Holoprosencephaly is, what tests you need, and the implication of having been diagnosed with Holoprosencephaly for you, your baby and your family.

Three classical forms of holoprosencephaly (HPE) of increasing severity are described based on the degree of anatomical separation: lobar, semi-lobar and alobar HPE. Milder subtypes include midline …