Janus kinase inhibitor - Wikipedia
JAK enzymes are part of the JAK/STAT pathway. This signaling pathway transmits chemical signals from the outside of cells, specifically lymphocytes, and into the cell nucleus.
What are JAK inhibitors and how do they work? - Drugs.com
Jul 15, 2025 · Janus kinase (JAK) inhibitors are a group of medicines that help block immune system signals in the body that can lead to swelling (inflammation) and pain in conditions like rheumatoid …
JAK Inhibitors: Uses, Types, Side Effects, and More
Aug 23, 2025 · In this article, learn about the dosage, uses, and ongoing research underway for JAK inhibitors available in the United States, as well as common side effects, contraindications, and …
Overview of the Janus kinase inhibitors for rheumatologic ... - UpToDate
Oct 22, 2025 · The Janus kinases (JAKs) are protein tyrosine kinases (TYKs) that bind to transmembrane type 1 and type 2 cytokine receptors and mediate cellular responses to numerous …
JAK Inhibitors 101 - The Rheumatologist
Jul 28, 2025 · The JAK-signal transducer and activator of transcription (STAT) pathway is central to immune dysregulation in many autoimmune diseases due to its role in transducing signals from an …
JAK inhibitors: an evidence-based choice of the most appropriate ...
Recently, Janus kinase inhibitors (JAKi) have been developed to block the effect of proinflammatory cytokines in IMIDs.
JAK inhibitors (JAKi): Mechanisms of action and perspectives in ...
Feb 1, 2025 · Understanding the cell signaling pathway, and more specifically the JAK STAT pathway, is a breakthrough in the era of biotherapies. JAKi are increasingly designed to target a single JAK …
Understanding the Mechanism of Action in JAK Inhibitors
Jun 2, 2024 · Jason Hawkes, MD, MS, medical dermatologist in Sacramento, California presented an in-depth overview on the mechanism of action (MOA) of Janus Kinase (JAK) inhibitors, a class of small …
JAK inhibitor selectivity: new opportunities, better drugs?
Sep 9, 2024 · In this update, we discuss the background of JAK inhibitors, current approved indications and adverse effects, along with new developments in this field.
JAK Inhibitors: Uses, Side Effects, and How They Work
Discover how JAK inhibitors work, their benefits for autoimmune conditions like rheumatoid arthritis, potential side effects, and precautions to consider before starting treatment.