Sep 22, 2022 · People may take PDE5 inhibitors to manage conditions such as erectile dysfunction (ED) or pulmonary hypertension. In this article, we explain how PDE5 inhibitors work and the potential risks...

Jul 25, 2025 · The PDE5 enzyme (phosphodiesterase type 5) is found in the human body. Its primary function is to break down cyclic guanosine monophosphate (cGMP), a molecule important in various …

PDE5 is an enzyme that accepts cGMP and breaks it down. Sildenafil, vardenafil and tadalafil are inhibitors of this enzyme, which bind to the catalytic site of PDE5.

Feb 1, 2021 · Here, we review the structure of PDE5, how its function is regulated, and discuss the clinically available inhibitors that target phosphodiesterase 5, aiming to better understand the …

Jun 8, 2022 · PDE-5: These are in your lungs and in your penis. Phosphodiesterase (PDE) inhibitors are medications that block those enzymes. Some PDE inhibitors are selective, meaning they target a …

Mar 4, 2025 · PDE5 inhibitors work by increasing the levels of cGMP and specifically target the penis and the lungs. PDE5 inhibitors can be used to treat erectile dysfunction by inducing smooth muscle …

In the present review, the pharmacological basis of the NO/cGMP pathway and the rationale and clinical use of PDE5 inhibitors in different diseases are discussed.