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All you need to know about excitation-contraction coupling failure is that the process of excitation-contraction coupling being disrupted is what leads to the accumulation of calcium ions inside of the cytoplasm. - The accumulation of calcium ions is what leads to muscle damage due to calpain activity and an inflammatory response. Well how can we reduce calcium ion accumulation so we don’t have calcium ion-related fatigue? - Avoiding lengthened partials, Training lower volume, and working with h
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Coach Kolt | Fitness Coach on Instagram: "Calcium ion fatigue: excitation contraction coupling failure - Calcium ions are required for muscle contractions. Mitochondria help clear it out, but after repeated contractions, mitochondrial overload happens. Poteases and calpains activate and start breaking the bridge (junctophilin 2) between the roads (T tubules) and the water tower (sarcoplasmic recticulum). Action potentials from the brain can no longer reach the water tower and that cell is now un
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