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High-intensity statins are defined as statins that lower LDL-C by ≥50%. - Atorvastatin 40–80 mg meets this criteria - Along with rosuvastatin 20–40 mg, it is one of the only true high-intensity statin options Why not the others? ❌ Simvastatin 20 mg → low-intensity ❌ Pravastatin 40 mg → moderate-intensity ❌ Lovastatin 20 mg → low-intensity Only atorvastatin at higher doses achieves the LDL reduction required for high-risk patients (e.g., ASCVD, LDL ≥190 mg/dL). NAPLEX Pearl: High-intensity statin
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Replying to @Rea 1404 ROSUVASTATIN LONG TERM SIDE EFFECTS Rosuvastatin (Crestor) is a high-potency statin that blocks cholesterol production in the liver. It’s often used when other statins aren’t strong enough, or when people have a high cardiovascular risk. But rosuvastatin has unique concerns compared to others: \t•\tHigher risk of muscle pain and weakness, especially at 20–40mg doses \t•\tCan increase creatine kinase (CK) and rarely cause rhabdomyolysis \t•\tGreater effect on kidneys than si
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