Methotrexate is one of the most important medications used in autoimmune conditions like rheumatoid arthritis. At low doses, it helps calm an overactive immune system, reduce inflammation, and protect joints from long-term damage. But it doesn’t work overnight — benefits often take weeks to months, and regular bloodwork is important to monitor safety. Folic acid is commonly used alongside methotrexate to help reduce side effects like nausea, fatigue, and mouth sores. Simple idea: methotrexate he